Everything about ceesdekker.net
Everything about ceesdekker.net
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Nanotechnology features a range of possibilities to lead to biology. Listed here I'll current examples exactly where nanofabrication – the chance to make confined constructions with dimensions at will – is utilised to look at the biophysics of solitary molecules and cells. I will current some examples from our lab:
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[Laughs] ‘It absolutely was unquestionably an awesome hazard! At enough time, I used to be effectively mindful that it could go Improper and that I could become significantly less prosperous, but I just overlooked that. Curiosity has often been my strongest driving force. And luckily everything worked out.’
A rhythmically pulsing leaf-spring DNA-origami nanoengine that drives a passive follower Mathias Centola
This yielded a breakthrough. Within just only a few months, we were being capable of evaluate transport by a person one-walled carbon nanotube. Depending on small-temperature experiments by a brilliant PhD university student in my group, Sander Tans (now a valued colleague and professor at Delft College of Technologies by having an active investigate lab at AMOLF in Amsterdam), we showed that carbon nanotubes ended up genuine quantum wires with incredibly long (micrometres) electronic coherence lengths — confirming theoretical predictions of metallic conduct.
Electrical transport in monolayers of phthalocyanine molecular wires and AFM imaging of a single wire bridging two electrodes
‘Initially we checked out Organic programs with a ceesdekker physical look at and acted on The premise of the resources we understood. It took a number of years before we started out Operating a lot more on the big biological troubles. I then began to simply call it nanobiology, a time period that didn't exist at enough time.
2011, to start with in vitro measurements of transportation throughout an individual biomimetic nuclear pore intricate; growth of multiplexed magnetic tweezers for kilo-molecule experiments; and settled the mechanism of homology recognition in DNA homologous recombination
The rotors harness energy from the nanoscale drinking water and ion stream that's created by a static chemical or electrochemical opportunity gradient during the nanopore, which happen to be recognized via a salt gradient or applied voltage, respectively. These artificial nanoengines self-organize and operate autonomously in physiological conditions, suggesting tips on how to constructing energy-transducing motors at nanoscale interfaces.
There was just one trouble though — we did not observe any measurable electrical conduction from the single polymer molecules. We concluded that at the single-molecule level, conducting polymers had been truly not these kinds of good conductors, which was alternatively disappointing. We thus broadened our view to try to find more promising molecules.
‘The concept There's this type of issue to be a beginning, an enormous bang, is now an interesting signpost to take into account that there was a creator. But additional generally, and on the basis of pure rationality, I also arrive at a Christian interpretation of actuality. An atheistic worldview can be a naturalistic worldview: basically, there are actually only atoms and natural forces that we are able to measure.
2006, initially demonstration of molecular sorting in a lab on the chip working with biomotors; discovery of nanobubbles in solid-state nanopores; and 1st estimate of electrokinetic Electrical power conversion inside a nanofluidic channel
Permit’s initially glimpse back in the mean time if you made a decision to change your concentration from superconductivity and nanotubes to biology at the conclusion of the 1990s.
2004, discovery of recent physics in translocation of DNA by way of nanopores; initial experimental analyze of ions conduction in nanofluidic channels; initially electrochemistry with personal one-wall carbon nanotubes; STM detection and Charge of phonons in carbon nanotubes; initial electrical docking of microtubules on kinesin-coated nanostructures; to start with biophysics characterization on the mechanical properties of double-stranded RNA; and initially single-molecule analyze of DNA translocation by a restriction-modification enzyme.